THE QUESTION OF THRESHOLD DOSES FOR RADIATION-DAMAGE - MALFORMATIONS INDUCED BY RADIATION EXPOSURE OF UNICELLULAR OR MULTICELLULAR PREIMPLANTATION STAGES OF THE MOUSE

Authors
MULLER WU STREFFER C PAMPFER S
Citation
Wu. Muller et al., THE QUESTION OF THRESHOLD DOSES FOR RADIATION-DAMAGE - MALFORMATIONS INDUCED BY RADIATION EXPOSURE OF UNICELLULAR OR MULTICELLULAR PREIMPLANTATION STAGES OF THE MOUSE, Radiation and environmental biophysics, 33(1), 1994, pp. 63-68
Citations number
9
Categorie Soggetti
Biophysics,"Radiology,Nuclear Medicine & Medical Imaging","Environmental Sciences
Journal title
Radiation and environmental biophysics → ACNP
ISSN journal
0301634X
Volume
33
Issue
1
Year of publication
1994
Pages
63 - 68
Database
ISI
SICI code
0301-634X(1994)33:1<63:TQOTDF>2.0.ZU;2-U
Abstract
Mouse embryos of the one-cell stage or the 32- to 64-cell stage were e xposed to various X-ray doses (one-cell stage: 0.25-2 Gy; 32- to 64-ce ll stage: 1-3 Gy). It turned out that the shape of the dose-response c urves is statistically compatible with the assumption derived from bio logical considerations that there is no threshold for radiation-induce d malformations in the case of the exposure of one-cell embryos, where as there is a threshold dose (close to 1 Gy) in the case of the exposu re of 32- to 64-cell embryos.