SYNTHESIS OF OLIGODEOXYRIBONUCLEOTIDES CONTAINING DIMERS WITH CARBAMATE MOIETIES AS REPLACEMENT OF THE NATURAL PHOSPHODIESTER LINKAGE

Authors
WALDNER A DEMESMAEKER A LEBRETON J
Citation
A. Waldner et al., SYNTHESIS OF OLIGODEOXYRIBONUCLEOTIDES CONTAINING DIMERS WITH CARBAMATE MOIETIES AS REPLACEMENT OF THE NATURAL PHOSPHODIESTER LINKAGE, Bioorganic & medicinal chemistry letters, 4(3), 1994, pp. 405-408
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
3
Year of publication
1994
Pages
405 - 408
Database
ISI
SICI code
0960-894X(1994)4:3<405:SOOCDW>2.0.ZU;2-I
Abstract
The synthesis of thymidine dimers containing both possible regioisomer ic carbamate moieties in place of the natural phosphodiester backbone is described. These dimers were incorporated in oligodeoxy-ribonucleot ides and melting temperatures (T-m) of the DNA/RNA and DNA/DNA duplexe s are reported. In addition the nuclease resistance of these single st rands were determined.