SYNTHESIS AND IN-VITRO CYTOTOXICITY OF 6-VINYLURIDINE AND RELATED-COMPOUNDS

Authors
MEGATI S SODUM R OTTER GM KLEIN RS OTTER BA
Citation
S. Megati et al., SYNTHESIS AND IN-VITRO CYTOTOXICITY OF 6-VINYLURIDINE AND RELATED-COMPOUNDS, Bioorganic & medicinal chemistry letters, 4(3), 1994, pp. 469-472
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
3
Year of publication
1994
Pages
469 - 472
Database
ISI
SICI code
0960-894X(1994)4:3<469:SAICO6>2.0.ZU;2-0
Abstract
The 6-alkenyluracil nucleosides (7a-e) and bases (14a-i) were synthesi zed and evaluated for their ability to inhibit the growth of mouse leu kemia L1210 cells in vitro. While several of the free bases are cytoto xic, with IC50 values in the 1 - 5 mu M range, the corresponding beta- D-ribofuranosyl nucleosides are not significantly active.