NOVEL CYTOTOXIC ANNONACEOUS ACETOGENINS - (2,4-CIS AND TRANS)-BULLADECINONES FROM ANNONA-BULLATA (ANNONACEAE)

Authors
GU ZM FANG XP ZENG L KOZLOWSKI JF MCLAUGHLIN JL
Citation
Zm. Gu et al., NOVEL CYTOTOXIC ANNONACEOUS ACETOGENINS - (2,4-CIS AND TRANS)-BULLADECINONES FROM ANNONA-BULLATA (ANNONACEAE), Bioorganic & medicinal chemistry letters, 4(3), 1994, pp. 473-478
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
3
Year of publication
1994
Pages
473 - 478
Database
ISI
SICI code
0960-894X(1994)4:3<473:NCAA-(>2.0.ZU;2-P
Abstract
A mixture of two novel cytotoxic adjacent bis-tetrahydrofuran (THF) ke tolactone acetogenins, (2,4-cis and trans)-bulladecinones (1 and 2), w as isolated from the bark of Annona bullara Rich, (Annonaceae). Adjace nt bis-THF rings, located at C-12 and C-16 and having only one adjacen t hydroxyl group, and the presence of an erythro vicinal diol in 1 and 2 are new features for the Annonaceous acetogenins.