CHIRAL REQUIREMENTS FOR TUMOR PROMOTERS - CONFORMATIONS AND ACTIVITY OF BENZOLACTAMS

Authors
ENDO Y OHNO M HIRANO M TAKEDA M ITAI A SHUDO K
Citation
Y. Endo et al., CHIRAL REQUIREMENTS FOR TUMOR PROMOTERS - CONFORMATIONS AND ACTIVITY OF BENZOLACTAMS, Bioorganic & medicinal chemistry letters, 4(3), 1994, pp. 491-494
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
3
Year of publication
1994
Pages
491 - 494
Database
ISI
SICI code
0960-894X(1994)4:3<491:CRFTP->2.0.ZU;2-A
Abstract
(-)-Benzolactam-V8-310 ((-)-1), which reproduces the twist conformatio n and biological activity of teleocidins, its antipode ((+)-1), and th e epi-benzolactams ((-)-2 and (+)-2) were synthesized as optically pur e forms. Structure-activity results indicate that the stereochemistry at C-5 plays a critical role in the binding to the receptor(s).