INDOLOCARBAZOLES .3. SYNTHESIS OF NOVEL AZA ANALOGS OF STAUROSPORINE AND K-252A AS PKC INHIBITORS

Authors
SHANKAR BB VIET AQ RIZVI R KIRKUP MP MCCOMBIE SW GANGULY AK
Citation
Bb. Shankar et al., INDOLOCARBAZOLES .3. SYNTHESIS OF NOVEL AZA ANALOGS OF STAUROSPORINE AND K-252A AS PKC INHIBITORS, Bioorganic & medicinal chemistry letters, 4(3), 1994, pp. 495-498
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
3
Year of publication
1994
Pages
495 - 498
Database
ISI
SICI code
0960-894X(1994)4:3<495:I.SONA>2.0.ZU;2-I
Abstract
Indolocarbazole 4 and arcyriaflavin A 19 reacted under basic condition s with 1-benzyl-2,6-bis (benzotriazolyl)-piperidine to give 5 and 20. As an extension of this methodology other related his benzotriazole de rivatives were synthesized and coupled with 19 to obtain a variety of aza derivatives 3. N-debenzylation of these compounds gave novel PKC i nhibitors.