CONFORMATIONALLY CONSTRAINED HIV-1 PROTEASE INHIBITORS

Authors
VACCA JP FITZGERALD PMD HOLLOWAY MK HUNGATE RW STARBUCK KE CHEN LJ DARKE PL ANDERSON PS HUFF JR
Citation
Jp. Vacca et al., CONFORMATIONALLY CONSTRAINED HIV-1 PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 4(3), 1994, pp. 499-504
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
3
Year of publication
1994
Pages
499 - 504
Database
ISI
SICI code
0960-894X(1994)4:3<499:CCHPI>2.0.ZU;2-M
Abstract
The synthesis and structure activity relationships of conformationally constrained analogs of the HIV-1 protease inhibitor L-685,434 are des cribed. In addition, the X-ray crystal structure of a complex between L-700,497 and the HIV-1 protease is shown.