SYSTEMATIC SPECIFICITY STUDIES ON PORPHOBILINOGEN DEAMINASE

Authors
CLEMENS KR PICHON C JACOBSON AR YONHIN P GONZALEZ MD SCOTT AI
Citation
Kr. Clemens et al., SYSTEMATIC SPECIFICITY STUDIES ON PORPHOBILINOGEN DEAMINASE, Bioorganic & medicinal chemistry letters, 4(3), 1994, pp. 521-524
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
3
Year of publication
1994
Pages
521 - 524
Database
ISI
SICI code
0960-894X(1994)4:3<521:SSSOPD>2.0.ZU;2-8
Abstract
Analogs of porphobilinogen (PBG) with different arrangements of the ac idic side chains at C-3 and C-4 were tested for their ability to form complexes (ES(x), x = 1-4) with PBG deaminase (EC 4.3.1.8), the enzyme responsible for the tetramerization of PBG into hydroxymethyibilane ( HMB). These studies show that an acidic side chain at C-4 in PBG is re quired for covalent interaction with the enzyme.