TIME-COURSE OF IRON-METABOLISM IN PATIENT S WITH HOMOZYGOTIC BETA-THALASSEMIA AFTER SPLENECTOMY

Authors
KUDRYAVTSEVA LM LEVINA AA KLIMANSKY VA TOKAREV YN
Citation
Lm. Kudryavtseva et al., TIME-COURSE OF IRON-METABOLISM IN PATIENT S WITH HOMOZYGOTIC BETA-THALASSEMIA AFTER SPLENECTOMY, Gematologia i transfuziologia, 38(9), 1993, pp. 8-10
Citations number
NO
Categorie Soggetti
Hematology
Journal title
Gematologia i transfuziologia → ACNP
ISSN journal
02345730
Volume
38
Issue
9
Year of publication
1993
Pages
8 - 10
Database
ISI
SICI code
0234-5730(1993)38:9<8:TOIIPS>2.0.ZU;2-L
Abstract
Iron metabolism was followed up in patients with homozygotic beta-thal assemia after 6 to 18 months, 2-3 years, and 4 to 12 years after splen ectomy. Iron reserves of the body were found gradually increasing with time, this being expressed in very high values of serum and red cell ferritins and serum iron. Noteworthy is also an increase of circulatin g immune complex levels and appearance of a ''free'' pool of iron. Thi s necessitates regular check-ups of iron metabolism parameters and tim ely correction of desferal dose.