TISSUE DESTRUCTION AS A MECHANISM INITIAT ING EXTERNAL PATHWAY OF HEMOSTASIS

Human and bovine brain tissues were used as a model to study phasic pa ttern and dynamic properties of lipid and protein components of damage d biological membranes as well as the relationships of this process wi th initiation of hemostasis external pathway. It was established that thromboplastic reaction is initiated by factor VII contact with the su rface of apoprotein III-containing membrane. Enhanced mobility of bord erline lipids correlated with thromboplastic activation of the membran e. The study made use of H-1, P-31-NMR and the test system specificall y sensitive to apoprotein III.