THERAPEUTIC AND PATHOGENETIC ASPECTS OF A RTICULAR AFFECTIONS IN HEMOPHILIA

This study was aimed at investigation of immune status in patients wit h hemophilic arthropathies and design of optimal therapeutic programs for them. 103 hemophiliacs were examined. Of them 56 patients had chro nic productive synovitis and 47 osteoarthrosis. All the patients displ ayed higher levels of CIC and immunoglobulins than normal subjects, th e highest values being registered in synovitis. Synovial fluid in them contained CIC and IgG, IgA, IgM. The findings suggest that immune dis orders are actively involved in pathogenesis of hemophilic arthropathi es. Programs of immunocorrecting therapy of synovitides and osteoarthr oses including plasmapheresis and intraarticular administration of hor monal and cytostatic drugs produced a clinical response in 80% of the cases. The remission lasted up to 1 year.