CRYSTAL AND MOLECULAR-STRUCTURES OF PYRIDAZINONE CARDIOVASCULAR AGENTS

The crystal and molecular structures of 11 6-substituted pyridazinone derivatives: 6-phenyl-3(2H)-pyridazinone-acetic acid (1/1) (1), 6-(4-a minophenyl)-3(2H)-pyridazinone (2), 6-(4-aminophenyl)-5-methyl-3(2H)-p yridazinone (3), 6-(4-acetamido-phenyl)-3(2H)-pyridazinone (4), 6-(4-a cetamido-2-methoxyphenyl)-3(2H)-pyridazinone (5), 6-(2-aminophenyl)-3( 2H)-pyridazinone (6), 6-phenyl-3(2H)-pyrazinone (7), 6-(4-aminophenyl) -4,5-dihydro-3(2H)-pyridazinone (8), do)phenyl]-4,5-dihydro-5-methyl-3 (2H)-pyridazinone (9). niophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazin one (-)-tartrate-dichloromethane-methanol (1/1/1) (10), 4,5-dihydro-6- methyl-3(2H)-pyridazinone (11) have been determined as part of a study to determine the relationship between their cardiovascular properties and molecular structure and dimensions. For the two optically resolve d chiral derivatives (9) and (10) the absolute configuration has been determined.