EEG POWER SPECTRA IN HUNTINGTONS-DISEASE - CLINICAL AND NEUROPSYCHOLOGICAL CORRELATES

Quantitative power spectral analysis (PSA) was applied to Frontal (F3, F4, F7, F8), temporal (T5, T6), and occipital (O1, O2) EEGs of 16 Hun tington's disease (HD) patients and eight healthy control subjects. PS A revealed HD patients' EEGs to be abnormal: (i) raw and percent Alpha power were reduced; (ii) raw and percent Theta power were reduced at F3 and F4; (iii) percent Delta and percent Beta power were increased; (iii) Theta Frequency was reduced by similar to 1.0 Hz. Frontal and te mporal EEG power measures and decreased EEG amplitude correlated with severity of neurological and cognitive impairment.