P. Lambelet et al., RADICAL EXCHANGE-REACTIONS BETWEEN VITAMIN-E, VITAMIN-C AND PHOSPHOLIPIDS IN AUTOXIDIZING POLYUNSATURATED LIPIDS, Free radical research, 20(1), 1994, pp. 1-10
Antioxidant reactions of mixtures of vitamin E, vitamin C and phosphol
ipids in autoxidizing lipids at 90 degrees C have been studied by ESR
spectroscopy. When the phospholipid contained a tertiary amine (e.g. p
hosphatidylcholine), the vitamin C and the vitamin E radicals were suc
cessively observed as these two vitamins were sequentially oxidised du
ring lipid oxidation. in the presence of the primary amine contained i
n phosphatidylserine, the vitamin E oxidation was delayed for a few ho
urs. in this case neither the vitamin C, nor the vitamin E radicals bu
t a nitroxide radical derived from the phospholipid was observed. Simi
lar results to those obtained with PS were obtained in the presence of
either phosphatidylethanolamine or soybean lecithin. The participatio
n in the radical reactions of phospholipids possessing a primary amine
can therefore explain the synergistic effect of these phospholipids i
n a mixture of vitamins E and C.