APOLIPOPROTEIN E-4 GENE DOSE IN CLINICALLY DIAGNOSED ALZHEIMERS-DISEASE - PREVALENCE, PLASMA-CHOLESTEROL LEVELS AND CEREBROVASCULAR CHANGE

Authors
CZECH C FORSTL H HENTSCHEL F MONNING U BESTHORN C GEIGERKABISCH C SATTEL H MASTERS C BEYREUTHER K
Citation
C. Czech et al., APOLIPOPROTEIN E-4 GENE DOSE IN CLINICALLY DIAGNOSED ALZHEIMERS-DISEASE - PREVALENCE, PLASMA-CHOLESTEROL LEVELS AND CEREBROVASCULAR CHANGE, European archives of psychiatry and clinical neuroscience, 243(5), 1994, pp. 291-292
Citations number
13
Categorie Soggetti
Psychiatry,Neurosciences
Journal title
European archives of psychiatry and clinical neuroscience → ACNP
ISSN journal
09401334
Volume
243
Issue
5
Year of publication
1994
Pages
291 - 292
Database
ISI
SICI code
0940-1334(1994)243:5<291:AEGDIC>2.0.ZU;2-O
Abstract
The prevalence of the apolipoprotein E-4 allele (ApoE-4) was significa ntly higher in a referral population of 40 patients with clinically di agnosed Alzheimer's disease than in a sample of non-demented elderly c ontrols (P < 0.01). The highest plasma cholesterol levels were found i n demented patients homozygotic for Apo E-4, but no significant increa ses of glucose, triglycerides and thyroxine or of leuko-araiosis and b rain infarcts were verified in this preliminary study.