EFFECTS OF HYPOLIPIDAEMICS CETABEN AND CLOFIBRATE ON MITOCHONDRIAL AND PEROXISOMAL ENZYMES OF RAT-LIVER

Clofibrate orcetaben was administered to male rats for 10 days. Peroxi somal and mitochondrial enzymes were assayed in liver subcellular frac tions. Clofibrate affected the specific activities of both mitochondri al enzymes (glycerol-3-phosphate dehydrogenase and nicotinamide-linked isocitrate dehydrogenase) and peroxisomal enzymes (fatty acyl-CoA oxi dase, glycerone phosphate acyltransferase, urate oxidase, and D-amino- acid oxidase). In contrast, cetaben raised only the peroxisomal enzyme s, acyl-CoA oxidase, glycerone-phosphate acyltransferase, D-amino-acid oxidase, catalase, and urate oxidase. Thus, the hypolipidaemic activi ty of these drugs may be exclusively related to stimulated peroxisomal functioning, while mitochondria play only a minor role.