ANTIBODY-MEDIATED INHIBITION OF ADHESION OF SHIGELLA-DYSENTERIAE-1 TOGUINEA-PIG COLONIC EPITHELIAL-CELLS IN-VITRO

Immunoglobulin G (IgG) fractions prepared from sera of Shigella dysent eriae 1 infected patients during the acute and convalescent phases of illness were found to be effective inhibitors of adhesion of S. dysent eriae cells to guinea pig colonic epithelial cells in vitro. The adhes ion could also be inhibited by whole sera, their IgG fractions, and Fa b fractions prepared from sera of rabbits immunized with whole bacteri a, the outer membrane (OM) and lipopolysaccharide. The adhesive capabi lity was best inhibited by the Fab fragment of antisera of rabbits imm unized with whole bacteria.