PROLONGED STABILIZATION OF MULTIPLE AND SINGLE BRAIN METASTASES FROM BREAST-CANCER WITH TAMOXIFEN - REPORT OF 3 CASES

Cancer frequently metastasizes to the brain, and such lesions, whether multiple or solitary, have a poor prognosis, despite all efforts to t reat them. There have been recent sporadic reports of brain metastases from breast cancer responding for some years to antiestrogens (partic ularly tamoxifen) or bromocryptine. We report three cases of brain met astasis from cancer - two multiple and one a solitary lesion. The long survival oi the patients - two for 5 years and one for 6 years, with more than an acceptable quality of life - should prompt therapeutic tr ials to test tamoxifen and designed to assess its effects on a sizable number of patients.