DESIGN AND SYNTHESIS OF ACTINIDE SPECIFIC CHELATORS - SYNTHESIS OF NEW CYCLAM TETRAHYDROXAMATE (CYTROX) AND CYCLAM TETRAACETONYLACETONE (CYTAC) CHELATORS

Molecular modeling shows that two new chelators, the cyclam tetrahydro xamate, 1, and the cyclam tetraacetonylaeetone derivative, 2, have pot ential for the binding of plutonium (IV). The synthesis of these chela tors has been achieved using short sequences from readily available cy clam. Both the details of the molecular modeling and the synthetic rou te to these molecules are described.