MARKED AND REPRODUCIBLE INCREASE IN TRILINEAGE BLOOD-CELL COUNTS BY ADMINISTRATION OF GRANULOCYTE-COLONY-STIMULATING FACTOR IN A PATIENT WITH REFRACTORY-ANEMIA WITH EXCESS BLASTS IN TRANSFORMATION
S. Chiba et al., MARKED AND REPRODUCIBLE INCREASE IN TRILINEAGE BLOOD-CELL COUNTS BY ADMINISTRATION OF GRANULOCYTE-COLONY-STIMULATING FACTOR IN A PATIENT WITH REFRACTORY-ANEMIA WITH EXCESS BLASTS IN TRANSFORMATION, British Journal of Haematology, 86(3), 1994, pp. 665-667
We report a patient with refractory anaemia with excess blasts in tran
sformation (RAEB-t) who presented with severe pancytopenia and receive
d four intermittent series of granulocyte colony-stimulating factor (G
-CSF) treatment over 1.5 years. In addition to the increase in mature
neutrophils, platelet count and haemoglobin level were dramatically in
creased. These haematological improvements were dependent on G-CSF dur
ing these treatment series. Bone marrow colony assay revealed that G-C
SF increased both CFU-E- and BFU-E-derived colonies in vitro. Clinical
usage of G-CSF in myelodysplastic syndrome (MDS) is discussed, with p
articular emphasis on mechanisms of trilineage response.