Acute febrile neutrophilic dermatosis (Sweet's syndrome) is a rare inf
lammatory disease of unknown cause characterized by painful, erythemat
ous plaques and a dermal infiltrate of mature neutrophils. Associated
systemic disease is a common finding in patients with Sweet's syndrome
, and in fact determines the prognosis; therefore, the diagnosis of Sw
eet's syndrome warrants a thorough medical evaluation. We found only 1
7 reported cases of Sweet's syndrome in children. Two cases of Sweet's
syndrome in children are presented; these cases are typical, except f
or the tibial pain in the first patient and the marked leukocytosis in
the second patient. Both patients responded promptly to systemic cort
icosteroid therapy, although both had relapse.