COMBINED THERAPY WITH INHALED NITRIC-OXIDE AND INTRAVENOUS PROSTACYCLIN IN AN INFANT WITH ALVEOLAR-CAPILLARY DYSPLASIA

Severe persistent pulmonary hypertension of the newborn (PPHN) remains a significant cause of neonatal morbidity and mortality with limited effective treatment options. We present the first case of a neonate wi th PPHN treated concurrently with inhaled nitric oxide (iNO) and intra venous prostacyclin (PGl(2)). He ultimately was diagnosed with alveola r-capillary dysplasia, a rare and fatal cause of pulmonary hypertensio n. However, his partial response to treatment demonstrates a possible role for combined therapy with iNO and PGl(2) in infants with severe P PHN.