ESTROGENIC RHYTHM INDUCED BY A SINGLE ADMINISTRATION OF THE EXTRACT OF FERULA-JAESCHKEANA TO IMMATURE RATS

The hexane extract of Ferula jaeschkeana was studied for its effects o n the oestrogenic rhythm following a single administration to immature rats. A 25 mg/kg single oral dose significantly increased the uterine wet weight and caused premature opening of the vagina and induced vag inal cornification. A uterotrophic peak was attained 2 days after admi nistration and thereafter declined gradually. At 10 days, values becam e almost normal. A significant amount of glycogen was estimated in the uterus during the first 5 days after administration and thereafter de creased significantly. Histoarchitecture of the uterus showed a stimul ated endometrium which continued for 6-8 days only. The oestrogenic rh ythm induced by the hexane extract was compared with that following di ethylstilbesterol administration.