ANTIULCER ACTIVITY OF THE STEM BARK EXTRACT OF ENTANDROPHRAGMA ANGOLENSE

Authors
NJAR VCO ADESANWO JK MAKINDE JM TAIWO OB
Citation
Vco. Njar et al., ANTIULCER ACTIVITY OF THE STEM BARK EXTRACT OF ENTANDROPHRAGMA ANGOLENSE, PTR. Phytotherapy research, 8(1), 1994, pp. 46-48
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
PTR. Phytotherapy research → ACNP
ISSN journal
0951418X
Volume
8
Issue
1
Year of publication
1994
Pages
46 - 48
Database
ISI
SICI code
0951-418X(1994)8:1<46:AAOTSB>2.0.ZU;2-K
Abstract
The effect of a methanol extract of the stem bark of Entandrophragma a ngolense was investigated on indomethacin-induced gastric ulcer in rat s. The effect of the extract was dose-dependent, doses ranging from 0. 4 to 1.6 g/kg produced significant effect (p < 0.05). At the highest d ose used (1.6 g/kg) complete inhibition of ulceration occurred. The pr obable mechanism of action of E. angolense is discussed.