THE MYOTONIN-PROTEIN KINASE PHOSPHORYLATES TYROSINE RESIDUES IN NORMAL HUMAN SKELETAL-MUSCLE

Authors
ETONGUEMAYER P FAURE R BOUCHARD JP THIBAULT MC PUYMIRAT J
Citation
P. Etonguemayer et al., THE MYOTONIN-PROTEIN KINASE PHOSPHORYLATES TYROSINE RESIDUES IN NORMAL HUMAN SKELETAL-MUSCLE, Biochemical and biophysical research communications, 199(1), 1994, pp. 89-92
Citations number
13
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
199
Issue
1
Year of publication
1994
Pages
89 - 92
Database
ISI
SICI code
0006-291X(1994)199:1<89:TMKPTR>2.0.ZU;2-C
Abstract
As a first approach to study the cellular events involved in myotonic dystrophy, we have produced a polyclonal antibody against a peptide se quence of the predicted gene product. This antibody specifically recog nizes a 54 kDa protein in human skeletal muscle. This protein phosphor ylates a co-polymer Glu/Tyr but not Myelin Basic Protein. This indicat es that the myotonin-protein kinase has a tyrosine kinase activity in human skeletal muscle. This is the first demonstration of the kinase a ctivity of the myotonin-protein kinase. (C) 1994 Academic Press, Inc.