W. Meyer et al., DEMONSTRATION OF NADPH-DIAPHORASE (NO-SYNTHASE) IN THE APOCRINE AND ECCRINE SKIN GLANDS OF DOMESTICATED MAMMALS, Cellular and molecular biology, 40(2), 1994, pp. 175-181
The study demonstrates a strong enzyme histochemical and immunohistoch
emical reaction staining for NADPH-diaphorase/NO-synthase in the secre
tory cells of the apocrine glands in the hairy skin, and the eccrine g
lands in the foot pads of domesticated mammals. The results obtained a
re discussed in view of a regulatory action of the NO generated by the
se enzyme activities, implying a direct influence of NO on the contrac
tile properties of glandular myoepithelial cells. In this way, a basic
and simple mechanism to couple secretion production and secretion ext
rusion can be proposed.