We present an exact calculation of the most general supersymmetric amp
litudes for K0-K0BAR and B0-B0BAR mixing resulting from gluino box dia
grams. We use these amplitudes to place general constraints on the mag
nitude of off-generational, flavor-changing mass mixings in the squark
mass matrices (with arbitrary chirality structures) that can arise bo
th in and beyond the minimal supersymmetric Standard Model (MSSM). We
use the renormalization-group equations to estimate these mass mixings
in the MSSM and in nonminimal supersymmetric models in terms of a gen
eral parameterization of universal soft supersymmetry breaking. We sho
w that while these mass mixings are too small in the MSSM to yield any
observable effects, the converse is true in most nontrivial extension
s of the MSSM, including supersymmetric GUTs. In nonminimal supersymme
try, the K(L)-K(S) mass difference is sensitive to such contributions
from supersymmetric particles with masses up to 100 TeV (10 TeV for th
e B(L)-B(S) mass difference), and the CP impurity parameter epsilon(K)
is sensitive to sparticle masses up to 1000 TeV. We show that supersy
mmetric CP violation can be predominantly ''superweak'' (i.e., contrib
ute mainly to epsilon(K)) or ''milliweak'' (epsilon') depending on the
chirality of the off-generational squark mass mixings. The rare decay
b --> sgamma is less sensitive than the aforementioned constraints, b
ut probes somewhat different squark mass mixings. The lepton-number vi
olating decay mu --> egamma is very sensitive to off-generational slep
ton mixing for sleptons up to a TeV. All these processes provide valua
ble information regarding the structure of physics beyond the MSSM per
taining to arbitrarily high mass scales, including the nature of super
symmetry breaking.