28-DAY CONTINUOUS DOSING STUDY IN MINIPIGS WITH A SALATRIM STRUCTUREDTRIACYLGLYCEROL COMPOSED OF STEARATE, ACETATE, AND PROPIONATE

SALATRIM 23SO lot A026 belongs to a family of structured triacylglycer ols with lower caloric availability (4.5-6.0 kcal/g) than corn oil (9 kcal/g). Male and female minipigs were divided into five groups of fou r pigs of each sex and fed diets containing 0 %, 3 %, 6 %, and 10 % SA LATRIM or 10 % corn oil, as a reference for the high fat content of th e SALATRIM diets, for 28 days. Diets were supplemented with 2 % corn-o il to ensure adequate essential fatty acid availability. No effects on body weight, feed consumption, clinical observations, hematology, Ser um chemistry, bone mineral content, serum and liver levels of fat-solu ble vitamins, and organ weights were detected. Focal hepatocellular va cuolation was observed in treated and control groups. The incidence wa s similar among groups. Because minimally increased severity of vacuol ation was observed in only one male in each of the 10 % SALATRIM and c orn oil treatments, this appears to be a spurious finding or a nonspec ific fat effect. SALATRIM 23SO lot A026 produced neither toxicological ly nor nutritionally significant effects.