MARKERS OF COAGULATION AND FIBRINOLYSIS IN BLOOD DRAWN INTO CITRATE WITH AND WITHOUT D-PHE-PRO-ARG-CHLOROMETHYLKETONE (PPACK)

In order to compare levels of Prothrombin Fragment 1+2 (F-1+2), Thromb in-antithrombin III complex (TAT), Fibrinogen Degradation Products (Fg DP) and Fibrin Degradation Products (FbDP) in plasma from blood drawn into sodium citrate with and without the protease inhibitor D-Phe-Pro- Arg-Chloromethylketone (PPACK), blood samples were collected from 41 p atients on the first day after elective gastric surgery. Levels of F-1 +2, TAT and FbDP were not significantly different in plasma with and w ithout PPACK. FgDP levels were significantly higher in plasma with PPA CK. Our results did not support previous suggestions that PPACK should be used as a routine anticoagulant for measurement of haemostatic act ivation products.