Hb. Rahr et al., MARKERS OF COAGULATION AND FIBRINOLYSIS IN BLOOD DRAWN INTO CITRATE WITH AND WITHOUT D-PHE-PRO-ARG-CHLOROMETHYLKETONE (PPACK), Thrombosis research, 73(5), 1994, pp. 279-284
In order to compare levels of Prothrombin Fragment 1+2 (F-1+2), Thromb
in-antithrombin III complex (TAT), Fibrinogen Degradation Products (Fg
DP) and Fibrin Degradation Products (FbDP) in plasma from blood drawn
into sodium citrate with and without the protease inhibitor D-Phe-Pro-
Arg-Chloromethylketone (PPACK), blood samples were collected from 41 p
atients on the first day after elective gastric surgery. Levels of F-1
+2, TAT and FbDP were not significantly different in plasma with and w
ithout PPACK. FgDP levels were significantly higher in plasma with PPA
CK. Our results did not support previous suggestions that PPACK should
be used as a routine anticoagulant for measurement of haemostatic act
ivation products.