MODULATION OF HYPOTHALAMIC PROTEIN-KINASE-C ACTIVITY BY ALPHA-GLYCERYL-PHOSPHORYL-O-SERINE (GPS) IN AGED RATS

Authors
ALEPPO G SORTINO MA SCAPAGNINI U CANONICO PL
Citation
G. Aleppo et al., MODULATION OF HYPOTHALAMIC PROTEIN-KINASE-C ACTIVITY BY ALPHA-GLYCERYL-PHOSPHORYL-O-SERINE (GPS) IN AGED RATS, Neuro endocrinology letters, 16(1), 1994, pp. 41-46
Citations number
11
Categorie Soggetti
Endocrynology & Metabolism",Neurosciences
Journal title
Neuro endocrinology letters → ACNP
ISSN journal
0172780X
Volume
16
Issue
1
Year of publication
1994
Pages
41 - 46
Database
ISI
SICI code
0172-780X(1994)16:1<41:MOHPAB>2.0.ZU;2-9
Abstract
A single treatment with GPS increased protein kinase C (PKC) activity in the particulate fraction of hypothalamic slices without affecting c ytosolic PKC. By contrast, a 30-day treatment with 100 mg/kg/die GPS d id not modify PKC activity in young animals while partially restoring the reduced cytosolic PKC activity observed in aged rats.