EFFECT OF RANITIDINE ON HYPOTHALAMIC-PITUITARY GONADAL-FUNCTION IN MAN

Authors
ROCCO A NARDONE MR PASTORE R MARTOCCHIA A PROIETTI A STIGLIANO A FALASCHI P
Citation
A. Rocco et al., EFFECT OF RANITIDINE ON HYPOTHALAMIC-PITUITARY GONADAL-FUNCTION IN MAN, Neuro endocrinology letters, 16(1), 1994, pp. 73-80
Citations number
24
Categorie Soggetti
Endocrynology & Metabolism",Neurosciences
Journal title
Neuro endocrinology letters → ACNP
ISSN journal
0172780X
Volume
16
Issue
1
Year of publication
1994
Pages
73 - 80
Database
ISI
SICI code
0172-780X(1994)16:1<73:EOROHG>2.0.ZU;2-E
Abstract
Ranitidine at the dose commonly used in the treatment of peptic ulcer and related acid-peptic disorders showed no effects on circulating lev els of T, E(2), FSH, LH, PRL and TSH as well as on spermatogenesis. Th e lack of anti-androgen properties of ranitidine may therefore be rega rded as a considerable advantage of the drug versus the first generati on of Hi-H-2 antagonists which have been shown able to interfere with the hypothalamic-pituitary-gonadal (HPG) axis in man.