AN ALKYLATIVE STRATEGY TO THE C-13 TO C-21 SECTOR OF DISCODERMOLIDE

Authors
YANG G MYLES DC
Citation
G. Yang et Dc. Myles, AN ALKYLATIVE STRATEGY TO THE C-13 TO C-21 SECTOR OF DISCODERMOLIDE, Tetrahedron letters, 35(9), 1994, pp. 1313-1316
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
9
Year of publication
1994
Pages
1313 - 1316
Database
ISI
SICI code
0040-4039(1994)35:9<1313:AASTTC>2.0.ZU;2-U
Abstract
An approach to the C-13 to C-21 sector of the immunosuppressive marine natural product discodermolide (1) is described. The C-15 to C-16 bon d is formed by diastereoselective alkylation of a ketone enolate. Eith er diastereomer of allkylation Can be obtained by selecting the approp riate counter ion. The C-16 to C-21 subunit is prepared in two steps f rom 11.