POLYMORPHISM IN MOLECULAR-CRYSTALS - STABILIZATION OF A METASTABLE FORM BY CONFORMATIONAL MIMICRY

Authors
DAVEY RJ BLAGDEN N POTTS GD DOCHERTY R
Citation
Rj. Davey et al., POLYMORPHISM IN MOLECULAR-CRYSTALS - STABILIZATION OF A METASTABLE FORM BY CONFORMATIONAL MIMICRY, Journal of the American Chemical Society, 119(7), 1997, pp. 1767-1772
Citations number
26
Categorie Soggetti
Chemistry
Journal title
Journal of the American Chemical Society → ACNP
ISSN journal
00027863
Volume
119
Issue
7
Year of publication
1997
Pages
1767 - 1772
Database
ISI
SICI code
0002-7863(1997)119:7<1767:PIM-SO>2.0.ZU;2-W
Abstract
A combined modeling and experimental strategy has been applied to the problem of stabilisation of a metastable conformational polymorph. For the first time additives have been successfully selected which by vir tue of their conformation are able to selectively inhibit the appearan ce of the stable beta polymorph of L-glutamic acid and hence stabilize the metastable alpha structure.