Am. Lavoie et Sjy. Mizumori, SPATIAL, MOVEMENT-SENSITIVE AND REWARD-SENSITIVE DISCHARGE BY MEDIAL VENTRAL STRIATUM NEURONS OF RATS, Brain research, 638(1-2), 1994, pp. 157-168
Previous behavioral and acute electrophysiological data have lead rese
archers to speculate that the nucleus accumbens integrates limbic, rew
ard and motor information [5,12,22,31]. The present study examined the
behavioral correlates to single unit activity of the nucleus accumben
s and surrounding ventral striatum as a means of evaluating the integr
ative functioning of this region in an awake animal. Medial ventral st
riatum (mVS) activity was recorded as rats completed multiple trials o
n an eight arm radial maze. Neuronal activity was found to correlate w
ith spatial, reward- and movement-related behavioral conditions. While
the majority of cells demonstrated correlates of a single type (i.e.
either spatial or reward correlates), 6 cells encoded multiple correla
tes of different types (i.e. spatial and reward correlates), The data
suggests that this integrative process can be active both at the level
of the individual neuron, and at the structural level. These results
are consistent with the hypothesis that the mVS integrates spatial and
reward-related information, which in turn influences voluntary motor
output structures in order to achieve accurate navigational behavior.