RECENT PROGRESS ON THE TOTAL SYNTHESIS OF BREFELDINS

This article deals with the total synthesis of brefeldins and the foll owing aspects of the synthesis are highlighted:(1) construction of the macrocyclic ring;(2) fundamental results by which the latter synthese s have been much influenced;(3) classical syntheses based on the above observations;(4) recent syntheses using stereoselective reactions;(5) syntheses based on the rearrangements and that starting with easily a vailable compounds of multi-chiral centers;(6) synthesis of brefeldin C and 7-epi-brefeldin A.