QUANTITATIVE-EVALUATION OF TC-99M-GSA IN THE RAT-LIVER AFTER ISCHEMIA-REPERFUSION INJURY

99(m)Tc-DTPA-galactosyl human serum albumin (Tc-GSA) is a new liver-im aging agent which binds specifically to hepatic binding protein. The p urpose of this study was to evaluate the usefulness of Tc-GSA in quant itatively evaluating hepatic ischemia-reperfusion injury in the rat. R egional hepatic ischemia was induced by clamping the left hepatic arte ry and the left portal vein for 5 to 45 min. A hepatic accumulation in dex (t(90)) was obtained on the basis of the dynamic data. A significa nt difference of this index was observed between all ischemic groups a nd the control. In conclusion, Tc-99m-GSA appears useful for evaluatin g the hepatic ischemia-reperfusion injury.