UNRESPONSIVENESS OF ANTIDONOR CYTOTOXIC T-CELLS IN A LONG-TERM STABLERENAL-TRANSPLANT RECIPIENT

The antidonor immune response was examined in a one haplotype-mismatch ed renal transplant recipient with an allograft that had been well-fun ctioning for more than 10 years. Although the relative response of the mixed lymphocyte reaction (MLR) was (45.8)% and the MLR responder cel ls stimulated by donor cells produced measurable amounts of interleuki n-2 (IL-2)(11.6 U/ml), the cytotoxic T lymphocytes (CTL) could not be generated against donor cells, even with exogenous IL-2. These results indicate that antidonor CTL precursors were either deleted or inactiv ated in this recipient.