IN-VITRO STUDIES ON THE DNA IMPAIRMENTS INDUCED BY CR(III) COMPLEXES WITH CELLULAR REDUCTANTS

The influence of Cr(III) complexes with ascorbic acid, cysteine and gl utathione on DNA has been studied spectrophotometrically and chromatog raphically. The toxic and genotoxic activities of these complexes were also investigated. It was found that these complexes bind to DNA weak er than hexaaqua Cr(III) complexes. It could be explained through the greater strength of the bi- and tridentate ligands coordinated to chro mium in comparison to water molecules. The formation of DNA-DNA interm olecular bonds and DNA interstrand cross-linking has been also observe d. These complexes were found to be non-toxic and non-genotoxic in the bacterial test.