COMPLICATED COGANS-SYNDROME WITH AORTIC-INSUFFICIENCY AND CORONARY STENOSIS

We describe a case of Cogan's syndrome in a 19-year-old woman with tin nitus, deafness, interstitial keratitis, and complicating aortic insuf ficiency and coronary stenosis. Serological testing revealed IgG and I gA antibodies against Chlamydia trachomatis. In spite of very high ant ibody titers there was no direct evidence for C. trachomatis in her ur ogenital smears or in biopsies of her aortic adventitia, and therefore these findings are of uncertain significance. Reconstruction of the a ortic valve and bypass surgery for an ostial stenosis of the left coro nary artery were necessary. Ten months after starting cyclosporine tre atment her course was stable and cochlear implant surgery was successf ully performed.