FOSCARNET FOR SUPPRESSION OF HUMAN-IMMUNODEFICIENCY-VIRUS REPLICATION

Authors
FLETCHER CV COLLIER AC RHAME FS BENNETT D PARA MF BEATTY CC JONES CE BALFOUR HH
Citation
Cv. Fletcher et al., FOSCARNET FOR SUPPRESSION OF HUMAN-IMMUNODEFICIENCY-VIRUS REPLICATION, Antimicrobial agents and chemotherapy, 38(3), 1994, pp. 604-607
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
38
Issue
3
Year of publication
1994
Pages
604 - 607
Database
ISI
SICI code
0066-4804(1994)38:3<604:FFSOHR>2.0.ZU;2-D
Abstract
The effect of foscarnet against human immunodeficiency virus (HIV) was evaluated in nine HIV-infected individuals; six completed 28 days of induction therapy. The overall mean increase in CD4(+) lymphocytes was 64 cells per mm(3). The mean decline in the HIV antigen concentration was 108 pg/ml (P = 0.03), and suppression was related to systemic fos carnet exposure by a maximum-effect pharmacodynamic model.