DEVELOPMENT OF EXPERIMENTAL RESPIRATORY-INFECTIONS IN NEUTROPENIC RATS WITH EITHER PENICILLIN-RESISTANT STREPTOCOCCUS-PNEUMONIAE OR BETA-LACTAMASE-PRODUCING HAEMOPHILUS-INFLUENZAE

Authors
SMITH GM ABBOTT KH
Citation
Gm. Smith et Kh. Abbott, DEVELOPMENT OF EXPERIMENTAL RESPIRATORY-INFECTIONS IN NEUTROPENIC RATS WITH EITHER PENICILLIN-RESISTANT STREPTOCOCCUS-PNEUMONIAE OR BETA-LACTAMASE-PRODUCING HAEMOPHILUS-INFLUENZAE, Antimicrobial agents and chemotherapy, 38(3), 1994, pp. 608-610
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
38
Issue
3
Year of publication
1994
Pages
608 - 610
Database
ISI
SICI code
0066-4804(1994)38:3<608:DOERIN>2.0.ZU;2-0
Abstract
Acute respiratory infections,vith penicillin-resistant strains of Stre ptococcus pneumoniae and a beta-lactamase-producing strain of Haemophi lus influenzae were established in neutropenic weanling rats. By use o f nonsurgical intrabronchial instillation of the bacteria suspended in molten agar, reproducible, acute respiratory infections suitable for experimental antibiotic efficacy studies were established.