IMPACT OF DOSING SCHEDULE UPON SUPPRESSION OF A RETROVIRUS IN A MURINE MODEL OF AIDS ENCEPHALOPATHY

Authors
BILELLO JA EISEMAN JL STANDIFORD HC DRUSANO GL
Citation
Ja. Bilello et al., IMPACT OF DOSING SCHEDULE UPON SUPPRESSION OF A RETROVIRUS IN A MURINE MODEL OF AIDS ENCEPHALOPATHY, Antimicrobial agents and chemotherapy, 38(3), 1994, pp. 628-631
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
38
Issue
3
Year of publication
1994
Pages
628 - 631
Database
ISI
SICI code
0066-4804(1994)38:3<628:IODSUS>2.0.ZU;2-Y
Abstract
We studied the impact of zidovudine (AZT) in Cas-Br-M murine leukemia virus-infected NFS-N mice after administration by once-daily bolus or continuous infusion. While higher peak concentrations of AZT were achi eved by once-daily dosing, continuous AZT infusion at 25 mu g/h mainta ined levels >1 mu M in plasma and >0.2 mu M in the brain. Continuous i nfusion provided significantly better viral inhibition, even though to tal doses were only one-third that of the once-daily therapy group.