EFFECT OF THE SULFONYLUREA GLYBURIDE ON SUPEROXIDE-DISMUTASE ACTIVITYIN ALLOXAN-INDUCED DIABETIC RAT HEPATOCYTES

Authors
ALTAN N ONGUN CO HASANOGLU E ENGIN A TUNCER C SINDEL S
Citation
N. Altan et al., EFFECT OF THE SULFONYLUREA GLYBURIDE ON SUPEROXIDE-DISMUTASE ACTIVITYIN ALLOXAN-INDUCED DIABETIC RAT HEPATOCYTES, Diabetes research and clinical practice, 22(2-3), 1994, pp. 95-98
Citations number
24
Categorie Soggetti
Gastroenterology & Hepatology","Endocrynology & Metabolism
Journal title
Diabetes research and clinical practice → ACNP
ISSN journal
01688227
Volume
22
Issue
2-3
Year of publication
1994
Pages
95 - 98
Database
ISI
SICI code
0168-8227(1994)22:2-3<95:EOTSGO>2.0.ZU;2-M
Abstract
In the present study we administrated glyburide (glibenclamide) to typ e 2 (NIDDM) diabetic rats and determined the effect of such treatment on liver superoxide dismutase (SOD) activity. Hepatic SOD activity was significantly reduced in diabetic animals. Glyburide treatment of dia betic rats for 4 weeks corrected the changes observed in diabetic live r. In addition, blood glucose levels of untreated diabetic rats decrea sed following glyburide treatment. Administration of glyburide to diab etic rats reversed the diabetes-induced changes, suggesting that glybu ride may directly increase liver SOD enzyme activity.