VISUALIZATION OF DAMAGED BRAIN-TISSUE AFTER ISCHEMIC STROKE WITH COBALT-55 POSITRON EMISSION TOMOGRAPHY

Authors
JANSEN HML PRUIM J VANDERVLIET AM PAANS AMJ HEW JM FRANSSEN EJF DEJONG BM KOSTERINK JGW HAAXMA R KORF J
Citation
Hml. Jansen et al., VISUALIZATION OF DAMAGED BRAIN-TISSUE AFTER ISCHEMIC STROKE WITH COBALT-55 POSITRON EMISSION TOMOGRAPHY, The Journal of nuclear medicine, 35(3), 1994, pp. 456-460
Citations number
21
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
The Journal of nuclear medicine → ACNP
ISSN journal
01615505
Volume
35
Issue
3
Year of publication
1994
Pages
456 - 460
Database
ISI
SICI code
0161-5505(1994)35:3<456:VODBAI>2.0.ZU;2-K
Abstract
In animal experiments, the radionuclide Co-55(2+) has been shown to ac cumulate in degenerating cerebral tissue similar to Ca2+. Methods: The potential role of Co-55(2+) for in vivo brain PET imaging was investi gated in four patients after ischemic stroke. Results: PET showed upta ke of Co-55(2+) in damaged brain tissue irrespective of blood-brain ba rrier integrity, as affirmed by CT and MRI. Conclusion: Our preliminar y results indicate that (CoCl2)-Co-55 may prove to be a useful and rel atively inexpensive PET radiopharmaceutical for visualization of degen erative processes in brain tissue.