A patient with a history of total thyroidectomy for papillary carcinom
a showed a solitary hot spot in the chest on post-therapy radioiodine
imaging. Subsequent evaluation demonstrated that this lesion was a pri
mary squamous-cell lung cancer. Our case illustrates a rare but import
ant differential diagnosis from lung metastatsis of thyroid cancer in
I-131 scintigraphy. Alternatively, this ''aberrant uptake'' might be a
rather common phenomenon for lung neoplasms, although the underlying
mechanism is not yet known. Future experimental studies might lead to
a new application of radioiodine imaging in pulmonary oncology.