SYNTHESIS OF THYL-(Z)-4-(PHENYLIMINO)NAPHTH[2,3-D]OXAZOL-9-ONE, A MONOIMINE QUINONE WITH SELECTIVE CYTOTOXICITY TOWARD CANCER-CELLS

Authors
BENEDETTIDOCTOROVICH V BURGESS EM LAMBROPOULOS J LEDNICER D VANDERVEER D ZALKOW LH
Citation
V. Benedettidoctorovich et al., SYNTHESIS OF THYL-(Z)-4-(PHENYLIMINO)NAPHTH[2,3-D]OXAZOL-9-ONE, A MONOIMINE QUINONE WITH SELECTIVE CYTOTOXICITY TOWARD CANCER-CELLS, Journal of medicinal chemistry, 37(5), 1994, pp. 710-712
Citations number
12
Categorie Soggetti
Chemistry Medicinal
Journal title
Journal of medicinal chemistry → ACNP
ISSN journal
00222623
Volume
37
Issue
5
Year of publication
1994
Pages
710 - 712
Database
ISI
SICI code
0022-2623(1994)37:5<710:SOTAM>2.0.ZU;2-H
Abstract
A regio and stereospecific synthesis of ethyl-(Z)-4-(phenylimino)napht h[2,3-d]oxazol-9-one (1) was achieved by using titanium tetrachloride in methylene chloride in the preparation of the imine. The regiochemis try was assigned by single-crystal X-ray analysis. In vitro tests show ed that this diastereomer is selectively active for some solid cancer tumors.