THE ROLE OF GENE CASSETTES IN AXIS FORMATION DURING DROSOPHILA OOGENESIS

Citation
H. Ruoholabaker et al., THE ROLE OF GENE CASSETTES IN AXIS FORMATION DURING DROSOPHILA OOGENESIS, Trends in genetics, 10(3), 1994, pp. 89-94
Citations number
44
Categorie Soggetti
Genetics & Heredity
Journal title
ISSN journal
01689525
Volume
10
Issue
3
Year of publication
1994
Pages
89 - 94
Database
ISI
SICI code
0168-9525(1994)10:3<89:TROGCI>2.0.ZU;2-V
Abstract
Establishment of the anteroposterior and dorsoventral axes of the fly originates during oogenesis and relies on signaling between the oocyte and the surrounding somatic follicle cells. Some genes originally ide ntified as playing a role in signaling during embryonic development al so mediate cell-cell communication during oogenesis. These genes have previously been grouped on the basis of their functions during embryog enesis, and this classification is largely maintained in oogenesis. Th e EGF receptor, the transmembrane protein rhomboid and proteins in the ras signal transduction pathway are required to initiate dorsoventral polarity, whereas the products of the neurogenic genes Notch and Delt a are necessary for formation of the anteroposterior axis in the oocyt e.