DETERMINATION OF BUTAZOLIDIN AND TANDERIL BY DIFFERENTIAL-PULSE VOLTAMMETRY IN AQUEOUS-ORGANIC MEDIA - APPLICATION TO BUTAZOLIDIN DETERMINATION IN VETERINARY DRUGS

A systematic study of butazolidin and tanderil electroanalytical deter mination method by differential pulse voltammetry is carried out in aq ueous-organic media because of their insolubility in water. Several pa rameters, such as solution pH, organic solvent/H2O(v/v) ratio, scan ra te, and temperature have been considered, showing that tanderil oxidat ion voltammograms can present two peaks depending on solution pH, wher eas butazolidin gives only one anodic peak at all the pH values. Both voltammograms can be used to establish electroanalytical methods of th ese drugs, giving a detection limit of 2.73 ppm for tanderil and 10.31 ppm for butazolidin. Moreover in spite of their slight peak potential diiferences, these drugs can be determined together in their mixtures . On the other hand, our method was applied to butazolidin determinati on in two veterinary formulations with very good results. The proposed instrumental method was validated with another instrumental method, t he Issa et al.'s spectrophotometric one, cited in references.