KINETIC SPECTROPHOTOMETRIC DETERMINATION OF IODIDE IN IODATED SALTS AND OF IODIDE OR CHLORPROMAZINE IN PHARMACEUTICALS

A kinetic study on the catalytic effect of iodide on the chlorpromazin e-H2O2 reaction is described. The reaction was followed spectrophotome trically by measuring the absorbance at 525 nm, absorption maximum of oxidation product of chlorpromazine. Under selected experimental condi tions (2 x 10(-2) M chlorpromazine, 2 M H3PO4, 0,3 M H2O2 and 20 +/- 0 ,1-degrees-C) iodide is determined between 13-254 ng mL-1. The reactio n has been applied to the determination of chlorpromazine between 3,6- 156 mug mL-1 (2 M H3PO4, 0,3 M H2O2. 20 +/-0,1-degrees-C, 2.5 mug mL-1 of I-). The influence of foreign oins was studied. The procedure was applied to the determination of iodide in iodinated salts and iodide o r chlorpromazine in pharmaceuticals.