STUDY OF THE POLAROGRAPHIC-BEHAVIOR AND THE POSSIBILITIES OF QUANTITATIVE-DETERMINATION OF SOME ORGANIC SULFUR-CONTAINING-COMPOUNDS, OF PHARMACEUTICAL INTEREST

Polarography, especially alternating current polarographic techniques and other voltametric techniques, play at present a proeminent part in the quantitative determination of some organic compounds of biologica l and pharmaceutical significance, In this respect, sulfur-containing compounds on the type of cephalosporins, compounds with antibiotica ac tion like penicilines, are easy reduced on the dropping mercury electr ode, in conditions of reversibility controlled by diffusion, which ass ure the obtaining of clearly defined and intense enough signals, which will permitted the quantitative determination of these compounds, in the concentration range 10(-3)-10(-7) mol 1, from biological media. Th e precision of the elaborated method is very good with a relative stan dard deviation of 1.5% for a concentration of 0.5 mug/nil, of the stud ied cephalosporin.